Volume 6, Issue 4, December 2020, Page: 64-70
Amelioration of Endosulfan Induced Hematological Alterations in Mice by Phyllanthus emblica and Withania somnifera
Pryuttma, Department of Zoology, GMRD College Mohanpur Samastipur, LNMU, Darbhanga, India
Parimal K. Khan, Department of Zoology, Patna Science College, Patna University, Patna, India
Received: Aug. 16, 2020;       Accepted: Sep. 11, 2020;       Published: Nov. 16, 2020
DOI: 10.11648/j.ajbes.20200604.11      View  27      Downloads  13
Abstract
Endosulfan is a man made insecticide which is highly controversial agrochemical due to its acute toxicity potential for bioaccumulation but still used in large scale in India even though it is being phased out globally. Endosulfan plays a great role in alteration of Hematological status of human beings. The present study was carried out to investigate the acute effects of endosulfan on Hematological parameters such as Erythrocyte count (RBC), Leucocyte count (WBC), percent Hemoglobin (Hb%), Packed cell volume (PCV%) and Mean Corpuscular Volume (MCV) on swiss albino mice. Adult male mice was segregated into four groups, each group with 6 animals. Group I, served as the control was administered with distilled water @0.1 ml/10gb.w; Group II, received endosulfan @3mg/kg b.w; Group III, concomitantly received Phyllanthus emblica; Group IV, concomitantly received Withania somnifera (Ashwagandha) 150 mg/kg b.w along with endosulfan through oral gavaging. All the treatments were continued for 3 months. The toxic effects observed upon endosulfan treatment include Erythrocyte count (RBC) gradually decreased, Leucocyte count (WBC) increased, percent Hemoglobin (Hb%) significantly decreased, Packed cell volume (PCV%) reduced significantly and Mean Corpuscular Volume (MCV) significantly increased. On contrast, treatment of extract of Phyllanthus emblica and Withania somnifera was found to alleviate the toxic consequences of endosulfan, thereby producing ameliorative effect.
Keywords
Endosulfan, Phyllanthus emblica, Withania somnifera, Erythrocyte Count, Leucocyte Count, Hemoglobin, Packed Cell Volume, Mean Corpuscular Volume
To cite this article
Pryuttma, Parimal K. Khan, Amelioration of Endosulfan Induced Hematological Alterations in Mice by Phyllanthus emblica and Withania somnifera, American Journal of Biological and Environmental Statistics. Vol. 6, No. 4, 2020, pp. 64-70. doi: 10.11648/j.ajbes.20200604.11
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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